Mild behavioral impairment linked to phenoconversion to Alzheimer’s disease and cortical thinning in mild cognitive impairment

Background Mild Behavioral Impairment (MBI) is a neurobehavioral syndrome characterized by later life emergence of sustained neuropsychiatric symptoms, as an at-risk state for dementia (Ismail Z, Alzheimers Dement, 2016). However, the associations between MBI and risk phenocoversion to its neuroanatomical correlates in MCI are still unclear. Method A total 1326 older adults with was followed mean 3.0 ± 2.0 years. approximated using transformation algorithm inventory at baseline. Two-step cluster analysis used explore classes 5 domains (decreased motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, abnormal perception/thought content). Cox regression applied investigate association clusters phenoconversion AD. subset participants (n = 225) underwent 3D T1-weighted MRI scans cortical thickness compared among domains. Result The identified 3 groups participants: (1) people without (47.8%, asymptomatic); (2) only dysregulation (29.3%, dysregulation); (3) relatively high probability dyscontrol (22.9%, multiple domains). Compared asymptomatic, associated higher AD (hazard ratio 2.589 [1.981 – 3.385], p < 0.001), but did not predict (1.204 [0.896 1.620], 0.219) (Fig 1). individuals symptoms revealed thinning bilateral superior inferior parietal, temporal, prefrontal cortex, right precuneus those 2). We find differences phenocoverter non-phenoconverter, interaction phenoconversion. Conclusion co-occuring Moreover, parietal precuneus, which have suggested signatures (Dickerson BC, Cereb Cortex, 2009). These results suggest that evaluation neuroimaging characteristics could be useful stratification individuals.